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Serv-U SFTP connection failing when using SFTP key and password
Reference this information when you have problems uploading very large files using the standard web client.
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When using various browsers on HTTPs link files larger than 4 GB are failing, this is due to a browser limit and not a default setting in Serv-u.
The best option is to use the Web Client Pro which is designed for dealing with larger files above 2 GB.
http://www.serv-u.com/wcp