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This article describes the issue when you see conversations with data transfer between certain nodes that total to 2 to 3TB of port 53 data over the course of an hour or less despite a proper Netflow configuration of your Cisco Catalyst 4500x.
All versions of NTA which you are monitoring a Cisco Catalyst 4500x
This is a known bug with an unconfirmed IOS version of the Cisco Catalyst 4500x.
You may want to consider upgrading to the latest firmware for that device, but it is best that you consult with Cisco TAC before proceeding with this. For reference:
Cisco IOS XE Release 3.8.0E